Expression and Clinical Significance of Micro Ribonucleic Acid-132 and Sex-Determining Region Y-Box 4 in Colon Cancer

This study aimed to investigate the expression and clinical significance of micro ribonucleic acid-132 sex-determining region Y-box 4 gene in colon cancer. Luciferase reporter system was used validate target directly regulated by acid-132. Transwell invasion assay test effect on invasiveness SW620 cells. Micro levels cancerous peri-cancerous tissues were measured using situ hybridization EleVisionTM immunohistochemistry staining. downregulated protein inhibited cancer In 72 tissue samples cancer, positive rate 18.1 % (13/72) 73.6 (53/72), both expressions showed significant differences as compared (p<0.01). significantly lower with lymph node metastasis than without Sex-determining elevated along Dukes stage increase higher accompanied more tumor depth (both p<0.05). Correlation analysis displayed negative correlation (r=-0.594, p=0.013). inhibits cell line via targeting 4. Low high could be important biomarkers for malignant transformation colonic mucosa Measuring molecules is valuable predicting